What is the difference between a male or female coton? For a companion that is neutered/spay, there really isn’t much difference. Both can be wonderful pets, both will try to dominate the humans and need regular training. Female cotons are in higher demand; therefore, the price is higher. Boys are lovers. I definitely recommend boys to families with young children, nothing seems to upset the boys. In my experience, females are more aloof, more protective of territory and bark more. There is a reason for the term Bitches.